Author: Todo Takeshi Kim Sang-Tae Otoshi Eriko Inui Taiichiro Kobayashi Hiroyuki Ohtsuka Eiko Toh Hiroyuki Ikenaga Mituo
Publisher: Oxford University Press
ISSN: 1362-4962
Source: Nucleic Acids Research, Vol.25, Iss.4, 1997-01, pp. : 764-768
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Abstract
Two types of enzyme utilizing light from the blue and near-UV spectral range (320–520 nm) are known to have related primary structures: DNA photolyase, which repairs UV-induced DNA damage in a light-dependent manner, and the blue light photoreceptor of plants, which mediates light-dependent regulation of seedling development. Cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6–4) pyrimidone photoproducts [(6–4)photoproducts] are the two major photoproducts produced in DNA by UV irradiation. Two types of photolyases have been identified, one specific for CPDs (CPD photolyase) and another specific for (6–4)photoproducts [(6–4)photolyase]. (6–4)Photolyase activity was first found in
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