Chapter
failure to detect differences in the DNA sequences present in differentiated cells
direct evidence for the variable gene activity theory of differentiation
Chapter 2. The onset of genome control ín embryogenesís
the species hybrid experiments and their conceptual background
evidence for delayed onset of embryo genome control from echinoderm species-hybrid studies
embryo genome control in the development of species-hybrids in higher deuterostomes
interpretation of the species-hybrid experiments
development in physically enucleated embryos
"chemical enucleation" : development of actinomycin-treated embryos
the timing of transcription for early genome-controlled morphogenesis
Chapter 3. Early molecular índíces of dífferentíatíon
protein synthesis in actinomycin-treated sea urchin embryos
the appearance of histospecific proteins
Chapter 4. RNA synthesís ín the early embryo
informational and ribosomal RNA synthesis in early Xenopus embryos
the amount of the genome active in the early morphogenesis of Xenopus: RNA-DNA hybridization studies
change in the informational content of the newly synthesized embryo RNA's
informational and ribosomal RNA synthesis in the early sea urchin embryo
change in the patterns of transcription during early echinoderm development
patterns of early gene activity in other deuterostomes
pattern of early gene activity in protostomes
summary of biochemical data regarding onset of various classes of RNA synthesis in the embryogenesis of diverse animals
Chapter 5. The fate and functíon of early ínformatíonal RNA
evidence suggesting that early gene products serve as templates for early embryo proteins
evidence that early gene products are stored for later utilization
Chapter 6. Maternal template RNA
the demonstration of maternal template RNA
extraction of maternal template RNA and the nature of its program
fertilization and the activation of the maternal program
Part II: cytoplasmíc localízatíon and the onset of dífferentíatíon
Chapter 1. The localízatíon phenomenon
Chapter 2. Localízatíon and preformatíonísm
the origins of late-nineteenth-century "neopreformationism"
neopreformationism and development in lower protostomes
Chapter 3. Defínítíve experímental evídence for localízatíon
the capabilities of isolated blastomeres
blastomere specification as a consequence of factors present in the egg cytoplasm
cytoplasmic localization in the embryogenesis of Dentalium and Ilyanassa
Chapter 4. Regulatíve and mosaíc development, and the uníversalíty of morphogenetíc determínants ín egg cytoplasm
the orientation of cleavage and the mosaic vs regulative dichotomy
time of appearance of definitive cytoplasmic organization in various eggs
lability of localization patterns
localization, regulative development, and mosaic development
Chapter 5. Demonstratíons of localízatíon in regulatíve embryos
cytoplasmic determinants in the eggs of echinoderms
cytoplasmic localization in amphibian eggs
the universality of cytoplasmic localization
Chapter 6. Interpretatíons of the localízatíon phenomenon
the "embryo in the rough"
localization and cell differentiation
recent evidence for the selective gene activation theory of localization
Part III: Gene functíon ín oogenesís
Chapter 1. Origin and dífferentíatíon of the female germ líne
general aspects of the timing of oogenesis in the chordate life cycle
panoistic and meroistic insect oogenesis
the occurrence of lampbrush chromosomes and the duration of the lampbrush stage
synopsis: temporal aspects of female germ-line differentiation
Chapter 2. Clues to oocyte genome functíon from organísms dísplayíng chromosome elímínatíon
Chapter 3. Accessory cell functíons ín oogenesís
the origin and physiological role of nurse cells
Chapter 4. Gene actívíty ín the oocyte nucleus: ríbosomal RNA synthesís
nucleolar function in the oocyte
the retention of ribosomal RNA synthesized in the amphibian oocyte
evidence that the free nucleoli of amphibian oocytes are the major sites of ribosomal RNA synthesis
nucleolar DNA and the selective replication of genes for ribosomal RNA
Chapter 5. Gene actívíty in the oocyte nucleus: synthesís of ínformatíonal RNA
the temporal location of informational RNA synthesis in oogenesis
lampbrush chromosome structure and DNA content
RNA synthesis in lampbrush chromosomes
the RNA and protein content of lampbrush chromosomes
informational RNA synthesis in the lampbrush-stage oocyte
the fate of lampbrush-synthesized informational RNA in later oogenesis
the fate of lampbrush-synthesized informational RNA in embryogenesis
the nature of the informational RNA inherited by the embryo
Chapter 6.
DNA of the oocyte cytoplasm
Part IV: ímmedíacy of gene control and the regulatíon of gene actívíty
Chapter 1. Very long-líved gene products
Chapter 2. Moderately long-líved ínformatíonal RNA
specific moderately long-lived template RNA's in the polysomes of differentiating tissues
a well-studied example: moderately long-lived template in hemoglobin-synthesizing cells
the presence of moderately long-lived template RNA and the repression of nuclear activity
moderately long-lived template RNA in microorganisms
Chapter 3. Rapídly decayíng template RNA
rapidly decaying template RNA in differentiated cells
the use of actinomycin in studies of template life
multiple levels of immediacy in gene control
significance of immediacy of gene control in the cellular genomic response system
changes of immediacy in embryonic development
Chapter 4. The rapídíty of varíatíons ín gene actívíty ín dífferentíated cells
Chapter 5. Characterístícs of bacteríal repressíon-derepressíon systems
the genetic basis for coordinate control and the generality of coordinate systems
polycistronic messenger RNA, the molecular basis of coordinate control
the operator gene concept
regulatory genes in coordinate and other systems
Chapter 6. Characterístícs of gene regulatíon systems ín dífferentíated cells
the proportion of the genome active in differentiated cells
relative change in gene function associated with change in state of differentiation
the nature of the repressive agents functioning in the differentiated cell genome
gene products of the differentiated cell nucleus
Chapter 7. Some hypotheses regardíng the nature of genomíc regulatíon ín dífferentíated cells
possible relevance of the operon concept
the nature of gene regulation in differentiated cells
Gene Activity in Early Development
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