Chapter
Chapter II Tumour Necrosis Factor Alpha Neutralization in the Medical Management of Crohn’s Disease
CD-A Historical Perspective
Common Symptoms, Diagnosis and Extra-Intestinal Manifestations
Clinical Patterns and Progression (The Vienna Classification)
Medical and Surgical Management
Development of Intestinal Inflammation in Crohn’s Disease
Physiological versus Pathological Inflammation, Barrier Function and Chronic Intestinal Inflammatory Responses
Molecular and Cellular Aspects of the Chronic Intestinal Inflammatory Response
Genetic, Environmental, Infectious, or All of the Above? Theories in Crohn’s Disease Aetiology
Role of TNF-α in Crohn’s Disease Pathophysiology
Seminal Publications on TNF-α in CD
TNF-α and T-lymphocyte activation
Macrophages and TNF-α in CD
TNF-α and Endothelial Activation in CD
Evidence That TNF-α Affects Epithelial Barrier Function in CD
Conflicting Evidence Regarding the Effect of TNF-α on Extracellular Matrix Remodelling in CD
Biological Therapy for CD
Infliximab (Remicade™) in Crohn’s Disease Management
Development of infliximab
Phase II trials of infliximab in CD
(1) Use in patients with actively draining fistulae
(2) Use in moderate to severe refractory disease
Phase III Trials of Infliximab in CD
New Horizons on Infliximab Use in CD-Prevention of Recurrence Post-resection
Other TNF-α Neutralizing Drugs: Experience in CD
Certolizumab pegol (CDP870, Cimzia™)
Anti-TNF-α Therapies That Failed to Meet F.D.A Criteria for Approval
Adverse Effects of TNF-α Neutralizing Therapy: Data from the Phase III Trial of Drugs Licensed to Date
Chapter III Tumor Necrosis Factor-α and Biliary Tract Diseases
TNF-αand Chronic Inflammatory Biliary Disease
Primary Biliary Cirrhosis
TNF-α and Cholangiocarcinoma
Chapter IV Tumoricidal Effect of Tumor Necrosis Factor-Alpha in Isolated Limb Perfusion Treatment of Human Cancers
Discovery of TNF-Alpha - A Historical Perspective
Use of RhTNF-Alpha as a Selective Anti-Cancer Agent
Mechanism of Selective Tumor Destruction by RhTNF-Alpha
Cell Adhesion Molecules (CAMS)
Von Willebrand Factor (VWF)
Endothelial Monocyte-Activating Polypeptide II (EMAP II)
VEGF Receptors, Flk-1 and Flt-1
Vascular Endothelial Cadherin (VE-Cadherin)
Nitric Oxide (NO) and Nitric Oxide Synthase (NOS)
Chapter V Tumor Necrosis Factor Antagonist Induced Psoriatic Skin Lesions
Chapter VI A New Promising Role of Melatonin in Promoting Tumor Necrosis Factor Toxicity in Cancer Cells
1. Melatonin: A Pineal Indole with Multiple Biological Functions
2. Melatonin Has a Role on Tumor Growth and Progression
3. Melatonin Promotes Immune Function in Vitro and in Vivo
4. Crosstalk between Melatonin and TNFα
Chapter VII Circulating TNF- α and Oral Health Condition in Elderly Japanese
Demographic and Medical Variables
Chapter VIII Tumor Necrotic Factor in T Cell Disorder: Hypothesis and Proof of Idea
Condition 1: Human Immunodeficiency Virus Infection Model
Condition 2: T Cell Leukemia Model
Condition 3: Hodgkin’s Lymphoma Model
Chapter IX Tumor Necrotic Factor in Malaria
Tumor Necrotic Factor in Plasmodium Vivax Infection
Tumor Necrotic Factor in Plasmodium Falciparum Infection
Tumor Necrotic Factor in Plasmodium Ovale Infection
Tumor Necrotic Factor in Plasmodium Malariae Infection
Tumor Necrotic Factor in Plasmodium Knowlesi Infection
Chapter X Tumor Necrosis with Special Reference to Autophagic Cell Death (Self-Cannibalism) and Xeno- Cannibalism in Gastric Cancer: Our Experience and Review of the Literature*
Molecular Executioners of Apoptosis
Deregulation of Apoptosis in Tumors
Molecular Mechanisms of Necrosis
The Apoptosis-Necrosis Continuum
Patterns of Tumor Necrosis
Pathogenesis of Tumor Necrosis
p53 Mutation and Necrosis in Thyroid Carcinomas
p53 Mutation and Necrosis in Invasive Breast Carcinomas
Luminal Subtype, HER2+/Estrogen Receptor (ER)- , and Basal-like Breast Cancers
Micropapillary Carcinomas
Tumor Cells can die in Several Ways
Immunogenic Versus Non-immunogenic Cell Death
Phagocytosis of Apoptotic Cells
Autophagy and Xeno-Cannibalism
Chapter XI Tumor Necrosis Factor and Carcinoma by Hepatitis B and C Virus Infection*
Hepatitis B and C Viruses
Cytokine Induction During Hepatic Inflammation
Relations between TNFα and Cancer and Liver Diseases
2. TNFα and Liver Diseases
TNFα and HBV and HCV Infection
1. Role of TNFα in HBV and HCV Infection
2. Association of TNFα Promoter Polymorphism with the Outcome of Hepatic Virus Infection
Anti-TNFα Therapy During HBV and HCV Infection
Tumor Necrosis Factor
( Cell Biology Research Progress )
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