Clinical Lung Cancer Mutation Detection
( A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer )
Publication series ： A Global Scientific Vision - Prevention, Diagnosis, and Treatment of Lung Cancer
Author： Stephan C. Jahn and Petr Starostik
Publisher： IntechOpen
Publication year： 2017
E-ISBN: INT6368767168
P-ISBN(Paperback): 9789535129653
P-ISBN(Hardback): 9789535129660
Subject： R56 Respiratory and thoracic diseases
Keyword： 呼吸系及胸部疾病
Language： ENG
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Clinical Lung Cancer Mutation Detection
Description
As the promise of personalized medicine in the treatment of cancer begins to be realized, the diagnostic techniques needed to drive that revolution have continued to evolve. What started as optical imaging of banded chromosomes for karyotyping has progressed to DNA sequencing and now next‐generation sequencing capable of producing billions of reads. There are currently a large number of techniques that are used in the clinical laboratory for assessing the presence of mutations in lung tumors, all with their own strengths and weaknesses. Here, we survey the technology that is available and take a closer look at next‐generation sequencing. We discuss the instruments that are currently on the market and demonstrate the common workflow from patient to data. Additionally, the outside factors that influence the use of these technologies, from government regulation to insurance reimbursement, are presented.
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