Ionizing Radiation Used in Drug Sterilization, Characterization of Radical Intermediates by Electron Spin Resonance (ESR) Analyses
( Evolution of Ionizing Radiation Research )
Publication series ： Evolution of Ionizing Radiation Research
Author： Şeyda Çolak
Publisher： IntechOpen
Publication year： 2015
E-ISBN: INT5933061052
P-ISBN(Paperback): 9789535121671
P-ISBN(Hardback): 9789535121671
Subject： O57 Nuclear physics, high energy physics
Keyword： 原子核物理学、高能物理学
Language： ENG
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Ionizing Radiation Used in Drug Sterilization, Characterization of Radical Intermediates by Electron Spin Resonance (ESR) Analyses
Description
In this study, the feasibility of radiation sterilization of drugs/drug raw materials is investigated by using Electron Spin Resonance (ESR) spectroscopy. Experimental data and their theoretical correspondings are presented for Sulfanilamide (SA), Sulfafurazole (SFZ), Sulfatiazole (STZ), Sulfacetamide Sodium (SS), Sulfamethazine (SMH), Butylated Hydroxyanisole (BHA), and Albendazole (ALB). Unirradiated samples exhibited no ESR signal whereas the irradiated samples showed ESR spectra consisting of different number of resonance lines indicating that radiolytic intermediates were produced upon irradiation. Increase in the absorbed dose did not create any pattern change in the ESR spectra of these samples. The results of ESR microwave power studies indicated that saturation is observed to be faster for the studies held below room temperatures. Low radiation yield (G=0.1-0.5) calculated by ESR data for the gamma-irradiated samples showed that these materials can not be used as sensitive dosimetric materials. No significant differences were observed between FT-IR spectra of the unirradiated and irradiated samples and this result is considered to be in agreement with the relatively small G value derived from ESR studies. The decay rates of the ESR peak heights of the samples irradiated at different doses and stored at normal and stability conditions were found to be independent of the irradiation doses. The contributing radical species were determined to decay with different decay
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