Front Cover

Advances in Radiation Biology

Copyright Page

Table of Contents

Contributors

Contents of Other Volumes

Chapter 1. The Role of Radiation and Chemicals in the Induction of Mutations and Epigenetic Changes during Carcinogenesis

I. Introduction

II. General Conceptual Overview

III. Mutations and Carcinogenesis

IV. An Integrative Theory of Carcinogenesis

V. Summary

ACKNOWLEDGMENTS

REFERENCES

Chapter 2. Radiation-Induced Vascular Injury and Its Relation to Late Effects in Normal Tissues

I. Introduction

II. Morphological Changes

III. Functional Changes

IV. Mechanisms Underlying Changes in Vascular Function

V. Response of Endothelial Cells

VI· The Role of Vascular Damage in Late Effects

VII. Summary

ACKNOWLEDGMENTS

REFERENCES

Chapter 3. Evaluation of Nitroheterocyclic Radiosensitizers Using Spheroids

I. Introduction

II. Sensitization of Spheroids

III. Cytotoxicity of Nitroheterocycles

IV. Applied Therapy

V. Other Effects of Nitroheterocycles

VI. Conclusions and Future Directions

REFERENCES

Chapter 4. Radiation-Induced Strand Breaks in DNA : Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects

I. Introduction

II. Frequency of DNA Strand Breaks after Ionizing Radiation

III. Enzymatic End Group Analysis in Irradiated DNA

IV. Chemical Analysis of Damage to the Sugar Moiety of Irradiated DNA

V. Mechanism of DNA Strand Break Formation by Ionizing Radiation Caused by Alterations of the Sugar Moiety

VI. Summary

REFERENCES

Chapter 5. Radiation-Induced Events and Their Time Scale in Mammalian Cells

I. Introduction

II. Models

III. Physical and Physicochemical Processes

IV. Chemical Processes

V. Biological Processes

VI. Implications

ACKNOWLEDGMENTS

REFERENCES

Chapter 6. Solid-State Radiation Chemistry of DNA: The Bases

I. Radiation Biology, DNA, and the Solid State

II. Evaluation of Free-Radical Assignments

III. Free-Radical Events Induced by Ionizing Radiation

IV. Notation

V. Pyrimidines

VI. Purines

VII. Base Complexes

VIII. DNA

IX. Closing Remarks

ACKNOWLEDGMENTS

REFERENCES

Chapter 7. Intrinsic Radiosensitivity of Proliferating Mammalian Cells

I. Introduction

II. Radiation Target(s)

III. Factors Determining Intrinsic Cellular Radiosensitivity

IV. Concluding Remarks

ACKNOWLEDGMENTS

REFERENCES

Chapter 8. Factors Governing the Use of Microwave/Radiofrequency Energies in Cancer Therapy

I. Introduction

II. Physical and Biophysical Principles

III. The Physiology of Temperature Regulation

IV. Rate of Microwave/Radiofrequency Energy Absorption in Living Systems

V. Electromagnetic Energy Absorbed Dose in Humans

VI. Specific Thermal Lesions

VII. Whole-Body Hyperthermia

VIII. Local Hyperthermia

IX. Engineering Considerations

X. Electromagnetic Field Measuring Instruments and Probes (Dosimetry)

XI. Problems and Perspectives

REFERENCES

Chapter 9. That Was the Basic Radfobiology That Was: A Selected Bibliography and Some Comments

I. Introduction

II. The Biophysical/Physicochemical Approach

III. Mathematical Models

IV. The Molecular-Biological/Biochemical Approach

V. Basic or Applied Research in Radiobiology

VI . Bibliographic Data on Radiobiology

VII. Textbooks

VIII. Monographs[M]

IX. Reviews [R]

X. Summary and Conclusions

GENERAL REFERENCES [G]

Index