Lung Transplantation: Therapies, Complications and Outcomes ( Organ Transplantation Research Horizons )

Publication series :Organ Transplantation Research Horizons

Author: Richard D. Ferguson;Craig A. Holmer  

Publisher: Nova Science Publishers, Inc.‎

Publication year: 2016

E-ISBN: 9781612094830

P-ISBN(Paperback): 9781611227604

Subject: L No classification

Keyword: 暂无分类

Language: ENG

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Lung Transplantation: Therapies, Complications and Outcomes

Chapter

Preconditioning in Lung Transplantation

Ischaemic Conditioning and Remote Ischaemic Conditioning

Evidence in Humans

Evidence in Lung Transplantation

Outcomes

Treatment

Supportive Management

Pulmonary Vasodilators

Surfactant

ECMO

Conclusion

References

Chapter 2

Intensive Care Management of Lung Transplant Recipient

Paolo Feltracco*, Eugenio Serra, Stefania Barbieri, Moira Milevoj, and Carlo Ori

Department of Anesthesia and Intensive Care, University Hospital of Padova,

Padova (Italy)

Abstract

Introduction

Physiology of the Transplanted Graft

Postoperative Hemodynamic Assessment and Stabilization

Fluid Management and Volumetric Monitoring

Primary Graft Dysfunction

Postoperative Management of Ventilation

Weaning from Mechanical Ventilation

Postoperative Pain Control

Acute Postoperative Physical Rehabilitation

Positioning

Infection Prophylaxys

Acute Rejection

Hyperacute Rejection

Postoperative Renal Complications

Immunosuppression

Gastrointestinal (GI) Complications

Coagulation Disorders

Conclusion

References

Chapter 3

Impact of Viral Pathogens in Lung Transplant Recipients

Cristina Costa1*, Massimiliano Bergallo1, Paolo Solidoro2, Sergio Baldi2, and Rossana Cavallo1

1Virology Unit, and 2Pulmonary Division; University Hospital S. Giovanni Battista di Torino. Via Santena 9 – 10126 Turin, Italy

Abstract

Introduction

Community Acquired Respiratory Viruses

Paramyxoviridae (Parainfluenzaviruses, Respiratory Syncytial Virus, Human Metapneumovirus)

Influenza Viruses

Rhinoviruses

Adenoviruses

Persistently Infecting Viruses: The Herpesviridae Family

Role of Β-Herpesviruses and Epstein-Barr Virus in the Lower Respiratory Tract From Lung Transplant Patients: Results of a Study Performed at the Virology Unit of the University Hospital San Giovanni Battista, Turin, Italy

Methods

Results

Discussion

Conclusion

References

Chapter 4

Identification of Allo- and Auto-Antibodies after Lung Transplantation

A.W.M. Paantjens1*, E.A. van de Graaf2, J.M. Kwakkel-van Erp2, W.G.J. van Ginkel1, T. Hoefnagel1, D.A. van Kessel3, J.M.M. van den Bosch3, and H.G. Otten1

1 Depts of Immunology

2 Pulmonology

3 Academic Medical Centre Utrecht and Pulmonology

Sint Antonius Ziekenhuis Nieuwegein, The Netherlands

Abstract

The Bronchiolitis Obliterans Syndrome After Lung Transplantation

Antibody Mediated Rejection

HLA Antibodies

Non-HLA Antibodies

Screening Strategies

Serological Proteome Analysis

Protein Arrays

SIMT

SEREX

Lung Transplantation

Kidney Transplantation

Stem Cell Transplantation

Conclusion

References

Chapter 5

Surgical Aspects of Lung Transplantation

Silvana Marasco 2, Adrian Pick1

1 Cardiothoracic Surgical Unit, The Alfred Hospital, Melbourne, Australia

2 Department of Surgery, Monash University, Australia

Abstract

Introduction

Access to the Thorax

Sternotomy

Clam-Shell Incision

Bilateral Anterolateral Thoracotomy

Anterior Axillary Muscle Sparing Thoracotomy

Posterolateral Thoracotomy

Recipient Pneumonectomy

Implantation

Bronchial Anastomotic Techniques

Pulmonary Vascular Anastomoses

Lung Size Reduction

Back Table versus In Situ Lobectomy

Choosing which Lobe to Resect

Choosing How Much Lung to Resect

Conclusion

References

Chapter 6

Neurologic Complications of Lung Transplantation

Sasha Živković

VA Pittsburgh HCS and University of Pittsburgh

Abstract

Abbreviations

1. Lung Transplantation

2. Neurologic Complications of Organ Transplantation

3. Neurologic Complications of Lung Transplantation

3.1. Disorders of Consciousness and Behavior

3.2. Seizures

3.3. Cerebrovascular Complications

3.4. Neuromuscular Complications

3.5 Immunosuppressant Neurotoxicity

3.6. Opportunistic Infections

3.7. Other Neurologic Complications

Conclusion

References

Chapter 7

Leucocyte Intracellular Cytokines

in Lung Transplant Patients - A More Physiological Indicator of Immunosuppression than Plasma Drug Levels

Greg Hodge1,2, Sandra Hodge1, Paul Reynolds1, Daniel Chambers3 and Mark Holmes1,4

Abstract

Introduction

Acute and Chronic Transplant Rejection

Immunosuppression

Corticosteroids

Calcineurin Inhibitors: Cyclosporin A (CsA) and Tacrolimus (Tac)

Antimetabolites: Azathioprine and Mycophenolate Mofetil

Anti-lymphocyte Antibodies

Anti-cytokine Receptor Antibodies

Cytokine Measurement in Lung Transplant Patients

Effect of Immunosuppression Protocols on Intracellular Cytokines in Blood T Cells

Effect of Immunosuppression Protocols on Blood Monocyte Cytokine and Chemokine Production

Effect of Current Immunosuppression Protocols on Intracellular Pro- and Anti-inflammatory Cytokines in Bronchoalveolar Lavage T Cells of Stable Lung Transplant Patients

Effect of Current Immunosuppression Protocols on Intracellular pro-Inflammatory Cytokines in Bronchial intra-epithelial T Cells of Stable Lung Transplant Patients

Airway Infection is Associated with Increased Immunosuppression of Intracellular Th1 Cytokines in Bronchoalveolar Lavage CD8+ T Cells Compared with Stable Lung Transplant Patients

Longitudinal Monitoring of Immunosuppression in Transplant Patients by Measurement of Intracellular T Cell Cytokines

Analysis of Intracellular Cytokines to Improve Therapeutic Immunosuppression Monitoring Following Lung Transplantation Now and in the Future

Conclusion

References

Chapter 8

Measurement of Intracellular Cytokines to Improve Therapeutic Monitoring of Immunosuppressive Drugs Following Lung Transplantation

Greg Hodge1,2, Sandra Hodge1, Paul Reynolds1 and Mark Holmes1

1 Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide;

2 Haematology Department, Women’s and Children’s Hospital,

North Adelaide, South Australia;

Abstract

Introduction

Allograft Rejection

Immunosuppressants

Corticosteroids

Calcineurin Inhibitors: Cyclosporin A (CsA) and Tacrolimus (Tac)

Antimetabolites: Azathioprine (AZA) and Mycophenolate Mofetil (MMF)

Anti-Lymphocyte Antibodies

Anti-Cytokine Receptor Antibodies

Measurement of Inflammatory Cytokines in Transplant Patients

Effect of Immunosuppression Protocols on Intracellular Cytokines in Blood T Cells

Effect of Immunosuppression Protocols on Blood Monocyte Intracellular Cytokine and Chemokine Production

Increased Intracellular Pro- and Anti-Inflammatory Cytokines in Bronchoalveolar Lavage T Cells of Stable Lung Transplant Patients

Compartmentalisation of Intracellular

Pro-Inflammatory Cytokines in Bronchial

Intra-Epithelial T Cells of Stable

Lung Transplant Patients

Airway Infection Is Associated with Decreased Intracellular Th1 Cytokines in Bronchoalveolar Lavage CD8+ T Cells of Stable Lung

Transplant Patients

Longitudinal Monitoring of Intracellular T Cell Cytokines in Transplant Patients

Future of Intracellular Cytokines to Improve Therapeutic Monitoring Following Lung Transplantation

References

Index

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