Bioinformatics :A Practical Guide to the Analysis of Genes and Proteins ( Methods of Biochemical Analysis )

Publication subTitle :A Practical Guide to the Analysis of Genes and Proteins

Publication series :Methods of Biochemical Analysis

Author: Andreas D. Baxevanis  

Publisher: John Wiley & Sons Inc‎

Publication year: 2004

E-ISBN: 9780471461012

P-ISBN(Hardback):  9780471383901

Subject: Q52 nucleic acid

Language: ENG

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Description

"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt."
—Eric Lander from the Foreword

Reviews from the First Edition

"...provides a broad overview of the basic tools for sequence analysis ... For biologists approaching this subject for the first time, it will be a very useful handbook to keep on the shelf after the first reading, close to the computer."
Nature Structural Biology

"...should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data."
Science

"...a wonderful primer designed to navigate the novice through the intricacies of in scripto analysis ... The accomplished gene searcher will also find this book a useful addition to their library ... an excellent reference to the principles of bioinformatics."
Trends in Biochemical Sciences

This new edition of the highly successful Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides a sound foundation of basic concepts, with practical discussions and comparisons of both computational tools and databases relevant to biological research.

Equipping biologists with the modern tools necessary to solve practical problems in sequence data analysis, the Second Edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. With chapters written by experts in the field, this up-to-date reference thoroughly covers vital concepts and is appropriate for both the novice and the experienced practitioner. Written in clear, simple language, the book is accessible to users without an advanced mathematical or computer science background. This new edition includes:

  • All new end-of-chapter Web resources, bibliographies, and problem sets
  • Accompanying Web site containing the answers to the problems, as well as links to relevant Web resources
  • New coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags
  • A glossary of commonly used terms in bioinformatics and genomics

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, positional cloning, clinical research, and computational biology.

Chapter

CONTENTS

pp.:  1 – 9

Foreword

pp.:  9 – 15

Preface

pp.:  15 – 17

Contributors

pp.:  17 – 19

2 THE NCBI DATA MODEL

pp.:  21 – 39

3 THE GENBANK SEQUENCE DATABASE

pp.:  39 – 65

4 SUBMITTING DNA SEQUENCES TO THE DATABASES

pp.:  65 – 85

5 STRUCTURE DATABASES

pp.:  85 – 103

6 GENOMIC MAPPING AND MAPPING DATABASES

pp.:  103 – 131

7 INFORMATION RETRIEVAL FROM BIOLOGICAL DATABASES

pp.:  131 – 175

8 SEQUENCE ALIGNMENT AND DATABASE SEARCHING

pp.:  175 – 207

9 CREATION AND ANALYSIS OF PROTEIN MULTIPLE SEQUENCE ALIGNMENTS

pp.:  207 – 235

10 PREDICTIVE METHODS USING DNA SEQUENCES

pp.:  235 – 253

11 PREDICTIVE METHODS USING PROTEIN SEQUENCES

pp.:  253 – 273

12 EXPRESSED SEQUENCE TAGS (ESTs)

pp.:  273 – 303

13 SEQUENCE ASSEMBLY AND FINISHING METHODS

pp.:  303 – 323

14 PHYLOGENETIC ANALYSIS

pp.:  323 – 343

15 COMPARATIVE GENOME ANALYSIS

pp.:  343 – 379

16 LARGE-SCALE GENOME ANALYSIS

pp.:  379 – 413

17 USING PERL TO FACILITATE BIOLOGICAL ANALYSIS

pp.:  413 – 433

Glossary

pp.:  433 – 471

Index

pp.:  471 – 477

LastPages

pp.:  477 – 506

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