Pathway Analysis for Drug Discovery ：Computational Infrastructure and Applications ( Wiley Series on Technologies for the Pharmaceutical Industry )

Publication subTitle ：Computational Infrastructure and Applications

Publication series ：Wiley Series on Technologies for the Pharmaceutical Industry

Author： Anton Yuryev  

Publisher： John Wiley & Sons Inc‎

Publication year： 2008

E-ISBN: 9780470399262

P-ISBN(Hardback):  9780470107058

Subject： R914.2 drug design

Language： ENG

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Description

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

Chapter

CONTENTS

pp.：  1 – 7

Preface

pp.：  7 – 9

Contributors

pp.：  9 – 11

1 Introduction to Pathway Analysis

pp.：  11 – 13

2 Software Infrastructure and Data Model for Pathway Analysis

pp.：  13 – 39

3 Automatic Pathway Inference in Heterogeneous Biological Association Networks

pp.：  39 – 59

4 Algorithmic Basis for Pathway Visualization

pp.：  59 – 79

5 Pathway Analysis of High-Throughput Experimental Data

pp.：  79 – 115

6 Integrative Pathway Analysis of Disease Molecular Data

pp.：  115 – 133

7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways, Potential Targets, and Noise

pp.：  133 – 161

8 Mammalian Proteome and Toxicant Network Analysis

pp.：  161 – 177

9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an Illustrative Example

pp.：  177 – 207

10 Impact of Chemistry Information on Pathway Analysis

pp.：  207 – 231

11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks

pp.：  231 – 249

12 An Adaptive System Model of the Yeast Glucose Sensor System

pp.：  249 – 275

13 Present and Future of Pathway Analysis in Drug Discovery

pp.：  275 – 297

Index

pp.：  297 – 309

LastPages

pp.：  309 – 332

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