Chromatin and Gene Regulation :Molecular Mechanisms in Epigenetics

Publication subTitle :Molecular Mechanisms in Epigenetics

Author: Bryan M. Turner  

Publisher: John Wiley & Sons Inc‎

Publication year: 2008

E-ISBN: 9780470751671

P-ISBN(Paperback): 9780865427433

P-ISBN(Hardback):  9780865427433

Subject: Q343.2 chromosome genetics theory (chromosome)

Language: ENG

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Description

Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors, and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.

Chapter

Contents

pp.:  1 – 9

Preface

pp.:  9 – 13

Prologue

pp.:  13 – 15

Chapter 3 The Nucleosome: Chromatin's Structural Unit

pp.:  39 – 58

Chapter 4 Histone Tails: Modifications and Epigenetic Information

pp.:  58 – 73

Chapter 5 Higher-Order Chromatin Structures and Nuclear Organization

pp.:  73 – 89

Chapter 6 Transcription in a Chromatin Environment

pp.:  89 – 115

Chapter 7 How the Transcription Machinery Deals with Chromatin

pp.:  115 – 140

Chapter 8 Chromatin Remodelling Machines

pp.:  140 – 160

Chapter 9 Heterochromatin

pp.:  160 – 186

Chapter 10 Long-term Silencing of Gene Expression

pp.:  186 – 210

Chapter 11 Cellular Memory and Imprinting

pp.:  210 – 235

Chapter 12 Mechanisms of Dosage Compensation

pp.:  235 – 263

Index

pp.:  263 – 289

LastPages

pp.:  289 – 298

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