Pharmacometrics ：The Science of Quantitative Pharmacology

Publication subTitle ：The Science of Quantitative Pharmacology

Author： Ene I. Ette  

Publisher： John Wiley & Sons Inc‎

Publication year： 2007

E-ISBN: 9780470087961

P-ISBN(Hardback):  9780471677833

Subject： R96 Pharmacology

Language： ENG

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Description

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians.

Edited and written by key leaders in the field, this flagship text on pharmacometrics:

  • Integrates theory and practice to let the reader apply principles and concepts.
  • Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field.
  • Is unique in including computer code information with the examples.

This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

Chapter

CONTENTS

pp.：  1 – 9

CONTRIBUTORS

pp.：  9 – 13

PREFACE

pp.：  13 – 17

ACKNOWLEDGMENTS

pp.：  17 – 21

1. Pharmacometrics: Impacting Drug Development and Pharmacotherapy

pp.：  21 – 23

PART I GENERAL PRINCIPLES

pp.：  23 – 45

PART II POPULATION PHARMACOKINETIC BASIS OF PHARMACOMETRICS

pp.：  45 – 285

PART III PHARMACOKINETICS / PHARMACODYNAMICS RELATIONSHIP: BIOMARKERS AND PHARMACOGENOMICS, PK/PD MODELS FOR CONTINUOUS DATA, AND PK/PD MODELS FOR OUTCOMES DATA

pp.：  285 – 477

PART IV CLINICAL TRIAL DESIGNS

pp.：  477 – 781

PART V PHARMACOMETRIC KNOWLEDGE CREATION

pp.：  781 – 849

PART VI PHARMACOMETRIC SERVICE AND COMMUNICATION

pp.：  849 – 923

PART VII SPECIFIC APPLICATION EXAMPLES

pp.：  923 – 957

INDEX

pp.：  957 – 1219

LastPages

pp.：  1219 – 1227

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