Cancer as a Metabolic Disease ：On the Origin, Management, and Prevention of Cancer

Publication subTitle ：On the Origin, Management, and Prevention of Cancer

Author： Thomas Seyfried

Publisher： John Wiley & Sons Inc‎

Publication year： 2012

E-ISBN: 9781118310298

P-ISBN(Hardback): 9780470584927

Subject： R730.5 tumor therapeutics

Language： ENG

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Description

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Chapter

pp.： 1 – 9

pp.： 9 – 15

pp.： 15 – 17

pp.： 17 – 19

2. Confusion Surrounds the Origin of Cancer

pp.： 19 – 33

3. Cancer Models

pp.： 33 – 49

4. Energetics of Normal Cells and Cancer Cells

pp.： 49 – 65

5. Respiratory Dysfunction in Cancer Cells

pp.： 65 – 91

6. The Warburg Dispute

pp.： 91 – 125

7. Is Respiration Normal in Cancer Cells?

pp.： 125 – 137

8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?

pp.： 137 – 151

9. Genes, Respiration, Viruses, and Cancer

pp.： 151 – 163

10. Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer

pp.： 163 – 195

11. Mitochondria: The Ultimate Tumor Suppressor

pp.： 195 – 213

12. Abnormalities in Growth Control, Telomerase Activity, Apoptosis, and Angiogenesis Linked to Mitochondrial Dysfunction

pp.： 213 – 225

13. Metastasis

pp.： 225 – 233

14. Mitochondrial Respiratory Dysfunction and the Extrachromosomal Origin of Cancer

pp.： 233 – 271

15. Nothing in Cancer Biology Makes Sense Except in the Light of Evolution

pp.： 271 – 279

16. Cancer Treatment Strategies

pp.： 279 – 295

17. Metabolic Management of Cancer

pp.： 295 – 309

18. Patient Implementation of Metabolic Therapies for Cancer Management

pp.： 309 – 373

19. Cancer Prevention

pp.： 373 – 393

20. Case Studies and Personal Experiences in Using the Ketogenic Diet for Cancer Management

pp.： 393 – 405

21. Conclusions

pp.： 405 – 423

Index

pp.： 423 – 427

LastPages

pp.： 427 – 472

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