Apoptosis and Autoimmunity ：From Mechanisms to Treatments

Publication subTitle ：From Mechanisms to Treatments

Author： Joachim R. Kalden  

Publisher： John Wiley & Sons Inc‎

Publication year： 2006

E-ISBN: 9783527605293

P-ISBN(Hardback):  9783527304424

Subject： R593.2 Autoimmune diseases, connective tissue diseases

Language： ENG

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Description

This is the first comprehensive book about the relationship between apoptosis and autoimmune diseases.
It offers a unique up-to-date overview on research results on the defective execution of apoptosis and the incomplete clearance of apoptotic cells. The molecular and cellular mechanisms involved are described in detail. As a possible consequence of apoptotic dysfunction, the development of severe autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) is discussed. An outlook on future research topics includes the evaluation of novel therapeutic strategies.

Chapter

Preface

pp.：  1 – 7

Contents

pp.：  7 – 9

List of Contributors

pp.：  9 – 19

Part 1 General Features of Apoptosis

pp.：  19 – 25

Part 2 Clearance of Apoptotic Cells

pp.：  25 – 61

Part 3 Autoimmunity Caused by Defective Execution of Apoptosis or Defective Clearance of Apoptotic Cells

pp.：  61 – 157

Part 4 Immunogenicity of Apoptotic Cells

pp.：  157 – 229

Part 5 “Altered Self ” in Dying Cells

pp.：  229 – 267

Part 6 The Role of DNA Binding Proteins for Systemic Autoimmunity

pp.：  267 – 341

Glossary

pp.：  341 – 367

Subject Index

pp.：  367 – 385

LastPages

pp.：  385 – 405

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