Amyloid Fibrils and Prefibrillar Aggregates ：Molecular and Biological Properties

Publication subTitle ：Molecular and Biological Properties

Author： Daniel Erik Otzen  

Publisher： John Wiley & Sons Inc‎

Publication year： 2013

E-ISBN: 9783527654215

P-ISBN(Hardback):  9783527332007

Subject： Q51 Protein

Language： ENG

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Description

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research.

The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Chapter

Contents

pp.：  1 – 9

Preface

pp.：  9 – 21

List of Contributors

pp.：  21 – 25

1 The Amyloid Phenomenon and Its Significance

pp.：  25 – 31

2 Amyloid Structures at the Atomic Level: Insights from Crystallography

pp.：  31 – 51

3 What Does Solid-State NMR Tell Us about Amyloid Structures?

pp.：  51 – 69

4 From Molecular to Supramolecular Amyloid Structures: Contributions from Fiber Diffraction and Electron Microscopy

pp.：  69 – 93

5 Structures of Aggregating Species by Small-Angle X-Ray Scattering

pp.：  93 – 115

6 Structural and Compositional Information about Pre-Amyloid Oligomers

pp.：  115 – 133

7 The Oligomer Species: Mechanistics and Biochemistry

pp.：  133 – 157

8 Pathways of Amyloid Formation

pp.：  157 – 181

9 Sequence-Based Prediction of Protein Behavior

pp.：  181 – 197

10 The Kinetics and Mechanisms of Amyloid Formation

pp.：  197 – 213

11 Fluorescence Spectroscopy as a Tool to Characterize Amyloid Oligomers and Fibrils

pp.：  213 – 241

12 Animal Models of Amyloid Diseases

pp.：  241 – 275

13 The Role of Aβ in Alzheimer’s Disease

pp.：  275 – 293

14 Experimental Approaches to Inducing Amyloid Aggregates

pp.：  293 – 325

15 Fibrillar Polymorphism

pp.：  325 – 351

16 Inhibitors of Amyloid and Oligomer Formation

pp.：  351 – 375

17 Development of Therapeutic Strategies for the Transthyretin Amyloidoses

pp.：  375 – 403

18 Hormone Amyloids in Sickness and in Health

pp.：  403 – 425

19 Functional Amyloids in Bacteria

pp.：  425 – 441

20 Structural Properties and Applications of Self-Assembling Peptides

pp.：  441 – 469

21 Harnessing the Self-Assembling Properties of Proteins in Spider Silk and Lung Surfactant

pp.：  469 – 485

Index

pp.：  485 – 501

LastPages

pp.：  501 – 511

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