Dendrimer-Based Drug Delivery Systems :From Theory to Practice ( Wiley Series in Drug Discovery and Development )

Publication subTitle :From Theory to Practice

Publication series :Wiley Series in Drug Discovery and Development

Author: Yiyun Cheng  

Publisher: John Wiley & Sons Inc‎

Publication year: 2012

E-ISBN: 9781118275207

P-ISBN(Hardback):  9780470460054

Subject: R914 pharmaceutical chemistry

Language: ENG

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Description

The opportunities and challenges of using dendrimers to improve drug delivery

Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs.

With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include:

  • Dendrimer history
  • Synthesis
  • Physicochemical properties
  • Principles of drug delivery
  • Applications in diverse biomedical fields

Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth.

Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.

Chapter

Contents

pp.:  1 – 7

Foreword

pp.:  7 – 9

Preface

pp.:  9 – 11

Acknowledgments

pp.:  11 – 13

Contributors

pp.:  13 – 15

About the Editor

pp.:  15 – 19

3 The Use of Dendrimers to Optimize the Physicochemical and Therapeutic Properties of Drugs

pp.:  75 – 113

4 Biological Properties of Phosphorus Dendrimers

pp.:  113 – 159

5 Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation

pp.:  159 – 177

6 Improving the Biocompatibility of Dendrimers in Drug Delivery

pp.:  177 – 227

7 Degradable Dendrimers for Drug Delivery

pp.:  227 – 259

8 Design of Stimuli-Responsive Dendrimers for Biomedical Purposes

pp.:  259 – 327

9 Dendrimer-Based Gene Delivery Systems: Administration Routes and In Vivo Evaluation

pp.:  327 – 349

10 Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities

pp.:  349 – 375

11 Dendrimer-Coated Carbohydrate Residues as Drug Delivery Trojan Horses in Glycoscience

pp.:  375 – 427

12 Nuclear Magnetic Resonance Techniques in the Analysis of Pamam Dendrimer-Based Drug Delivery Systems

pp.:  427 – 459

13 Dendrimer-Based Medical Nanodevices for Magnetic Resonance Imaging Applications

pp.:  459 – 483

14 Dendrimer-Related Nanoparticle System for Computed Tomography Imaging

pp.:  483 – 499

Index

pp.:  499 – 521

Supplemental Images

pp.:  521 – 535

LastPages

pp.:  535 – 544

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