Molecular Analysis and Genome Discovery

Author： Ralph Rapley  

Publisher： John Wiley & Sons Inc‎

Publication year： 2005

E-ISBN: 9780470020197

P-ISBN(Paperback): 9780471499190

P-ISBN(Hardback):  9780471498476

Subject： R446 laboratory diagnosis

Language： ENG

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Description

This advanced level textbook provides a comprehensive overview of recent developments in the area of molecular based diagnostics (including nucleic acids, biosensors and immunoessays) of disease markers. It also covers the impact of techniques such as in vitro nucleic acid amplifications (e.g. PCR) and other amplification methods, as well as gene and biochip production and automated techniques such as fluorescent sequencing.

The book discusses key concepts where new and merging areas, including pharmacogenomics, proteomics and functional genomics, are being researched and developed. In addition, examples are given where this new area of bioscience has or may be successfully applied.

Chapter

Contents

pp.：  1 – 7

Preface

pp.：  7 – 13

List of contributors

pp.：  13 – 15

1 Pharmacogenetics and Pharmacogenomics: An Overview

pp.：  15 – 19

2 Quantitative TaqMan Real-time PCR: Diagnostic and Scientific Applications

pp.：  19 – 35

3 Hybridization Probes for Real-time PCR

pp.：  35 – 47

4 An Overview of Genotyping and Single Nucleotide Polymorphisms (SNP)

pp.：  47 – 61

5 High-throughput Mutation Screening

pp.：  61 – 89

6 Determination of Nucleic Acid Sequences by Pyrosequencing

pp.：  89 – 119

7 An Introduction to DNA Chips

pp.：  119 – 131

8 Overview of Microarrays in Genomic Analysis

pp.：  131 – 145

9 Overview of Differential Gene Expression by High-throughput Analysis

pp.：  145 – 185

10 Aptamers: Powerful Molecular Tools for Therapeutics and Diagnostics

pp.：  185 – 209

11 Chip-based Proteomics Technology

pp.：  209 – 235

12 Infectomics Overview: Holistic and Integrative Studies of Infectious Diseases

pp.：  235 – 269

13 The Drug Discovery Process

pp.：  269 – 289

14 Structure-based Drug Discovery

pp.：  289 – 313

15 Protein Interaction-targeted Drug Discovery

pp.：  313 – 341

16 Overview of Quantitative Structure–Activity Relationships (QSAR)

pp.：  341 – 365

Index

pp.：  365 – 387

LastPages

pp.：  387 – 390

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