Preparative Enantioselective Chromatography

Author: Geoffrey B. Cox  

Publisher: John Wiley & Sons Inc‎

Publication year: 2008

E-ISBN: 9781405144711

P-ISBN(Hardback):  9781405118705

Subject: O658.1 chromatographic adsorption (chromatography) analysis

Language: ENG

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Description

The development of chiral liquid chromatography, facilitating the straightforward separation of enantiomers, was a significant advance in chromatography, leading to widespread application in analytical chemistry. Application in preparative chromatography has been less rapid, but with the development of single enantiomer pharmaceuticals its use is increasingly common in chemical synthesis at laboratory, pilot plant and even full production scale.


  • Brings non-experts up to speed quickly and comprehensively, facilitating the rapid development of effective separations of enantiomeric mixtures on a range of process scales
  • Presents case studies drawn from within the pharmaceutical industry to clearly illustrate the utility and value of preparative scale enantioselective chromatography in chemical research, development and production
  • Key reference source and entry to the literature so the reader does not have to engage in expensive and time consuming literature searching

Chapter

Contributors

pp.:  1 – 13

Preface

pp.:  13 – 15

3 Chiral stationary phases for preparative enantioselective chromatography

pp.:  35 – 64

4 Method development for preparative enantioselective chromatography

pp.:  64 – 94

5 Scaling-up of preparative chromatographic enantiomer separations

pp.:  94 – 126

6 Steady-state recycling and its use in chiral separations

pp.:  126 – 165

7 Simulated moving bed and related techniques

pp.:  165 – 192

8 Preparative-scale supercritical fluid chromatography

pp.:  192 – 221

9 Equipment for preparative and large size enantioselective chromatography

pp.:  221 – 240

10 Case study in production-scale multicolumn continuous chromatography

pp.:  240 – 269

11 Contract manufacturing and outsourcing considerations

pp.:  269 – 293

Appendix: advanced concepts

pp.:  293 – 319

Index

pp.:  319 – 341

LastPages

pp.:  341 – 346

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