Neopterin :Biochemistry - Methods - Clinical Application

Publication subTitle :Biochemistry - Methods - Clinical Application

Author: Helmut Wachter   Dietmar Fuchs   Arno Hausen   Gilbert Reibnegger   G. Weiss   E. R. Werner   G. Werner-Felmayer   A. Butenandt   H. Remboldt  

Publisher: De Gruyter‎

Publication year: 1992

E-ISBN: 9783110852783

P-ISBN(Paperback): 9783110117905

Subject:

Language: GER

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Chapter

1 Pteridines

pp.:  1 – 15

1.1 Historical remarks

pp.:  15 – 16

1.3 Biosynthesis

pp.:  16 – 17

1.2 Occurrence

pp.:  16 – 16

1.4 Biochemical functions

pp.:  17 – 18

References

pp.:  18 – 19

2 Neopterin

pp.:  19 – 21

2.2 Catabolism

pp.:  21 – 22

2.1 Chemical characteristics

pp.:  21 – 21

3 Measurement of Neopterin

pp.:  23 – 27

References

pp.:  23 – 23

3.1 Historical remarks

pp.:  27 – 27

References

pp.:  36 – 37

4 Normal Ranges of Neopterin Concentrations in Various Body Fluids

pp.:  37 – 39

4.1 Normal ranges of neopterin concentrations in urine

pp.:  39 – 40

4.2 Normal ranges of neopterin concentrations in serum

pp.:  40 – 42

4.3 Normal ranges of neopterin concentrations in cerebrospinal fluid

pp.:  42 – 43

4.4 Normal ranges of neopterin concentrations in synovial fluid

pp.:  43 – 44

4.5 Normal ranges of neopterin concentrations in saliva

pp.:  44 – 45

References

pp.:  45 – 45

5 Biosynthesis of Pteridines and the Human Immune System

pp.:  45 – 47

4.6 Discussion

pp.:  45 – 45

5.2 Cytokines and pteridine biosynthesis

pp.:  47 – 48

5.1 Immunological activation and cytokines

pp.:  47 – 47

5.3 Inducers of pteridine synthesis in human cells

pp.:  48 – 52

5.4 Cell culture techniques

pp.:  52 – 54

5.5 Determination of pteridines in cell homogenates and supernatants

pp.:  54 – 58

5.6 Enzyme activities of pteridine synthesis in cell extracts

pp.:  58 – 60

5.7 Biological significance of cytokine-induced pteridine synthesis

pp.:  60 – 62

References

pp.:  62 – 66

6 Neopterin in Organ Transplantation

pp.:  66 – 69

6.1 Renal transplantation

pp.:  69 – 70

6.2 Transplantation of solid organs other than kidney

pp.:  70 – 82

6.3 Transplantation of bone marrow

pp.:  82 – 86

References

pp.:  86 – 88

7 Neopterin in Autoimmune Diseases and Related Inflammatory Disorders

pp.:  88 – 91

7.1 Neopterin in rheumatoid arthritis

pp.:  91 – 92

7.2 Neopterin in inflammatory bowel diseases

pp.:  92 – 101

7.3 Neopterin in autoimmune diabetes

pp.:  101 – 109

7.4 Neopterin in autoimmune diseases of the thyroid

pp.:  109 – 111

7.5 Neopterin in systemic lupus erythematosus

pp.:  111 – 111

7.6 Neopterin in multiple sclerosis

pp.:  111 – 113

7.7 Neopterin in sarcoidosis

pp.:  113 – 115

7.8 Neopterin in celiac disease

pp.:  115 – 118

References

pp.:  118 – 119

8 Neopterin in Malignant Diseases

pp.:  119 – 123

8.1 Hematological malignancies

pp.:  123 – 124

8.2 Gynecological malignancies

pp.:  124 – 131

8.3 Malignancies of the urogenital tract

pp.:  131 – 158

8.4 Lung cancer

pp.:  158 – 162

8.5 Gastrointestinal, pancreatic and hepatic cancer

pp.:  162 – 169

8.6 Breast cancer

pp.:  169 – 175

8.7 Cancers of the head and neck region

pp.:  175 – 177

8.8 Malignant melanoma

pp.:  177 – 177

8.9 Neopterin in malignant diseases - a summary

pp.:  177 – 178

References

pp.:  178 – 179

9 Neopterin in Infectious Diseases

pp.:  179 – 183

9.1 Infections by viruses

pp.:  183 – 184

9.2 Neopterin during infection by human immunodeficiency virus type 1 (HIV-1) and the acquired immunodeficiency syndrome (AIDS)

pp.:  184 – 200

9.3 Infections by intracellular protozoa

pp.:  200 – 251

9.4 Infections by bacteria

pp.:  251 – 261

9.5 Neopterin during sepsis and trauma

pp.:  261 – 268

References

pp.:  268 – 271

10 Monitoring of Immunostimulatory Therapy

pp.:  271 – 279

References

pp.:  279 – 286

11 Neopterin in Transfusion Medicine

pp.:  286 – 289

References

pp.:  289 – 294

Appendix

pp.:  294 – 295

References

pp.:  295 – 299

Subject Index

pp.:  299 – 301

LastPages

pp.:  301 – 309

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