Hepatotoxicity :From Genomics to In Vitro and In Vivo Models

Publication subTitle :From Genomics to In Vitro and In Vivo Models

Author: Saura C. Sahu  

Publisher: John Wiley & Sons Inc‎

Publication year: 2008

E-ISBN: 9780470516744

P-ISBN(Hardback):  9780470057162

Subject: R575.1 hepatitis

Language: ENG

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Description

This book addresses all the current, up-to-date developments in this scientific discipline. Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals.

Contributions from leading investigators in hepatotoxicity research address current developments in this scientific discipline and discuss use of current cutting edge technology such as microarrays in hepatotoxicity thus providing a better understanding of hepatotoxins, their interactions and mechanisms of action.

This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science.

Chapter

Contents

pp.:  9 – 13

Contributors

pp.:  13 – 19

Preface

pp.:  19 – 21

Acknowledgements

pp.:  21 – 23

Section 2 Hepatocyte Cultures

pp.:  161 – 197

Section 3 Biomarkers of Hepatotoxicity

pp.:  197 – 211

Section 4 Mechanisms of Hepatotoxicity

pp.:  211 – 469

Section 5 Genomics of Hepatotoxicity

pp.:  469 – 559

Section 6 Gender Differences in Hepatotoxicity

pp.:  559 – 585

Section 7 Hepatotoxicity and Hepatocarcinogenicity

pp.:  585 – 611

Section 8 Hepatotoxicity and Botanical Supplements

pp.:  611 – 629

Section 9 Risk Analysis of Hepatotoxins

pp.:  629 – 657

Index

pp.:  657 – 704

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