Nanotoxicity ：From In Vivo and In Vitro Models to Health Risks

Publication subTitle ：From In Vivo and In Vitro Models to Health Risks

Author： Saura C. Sahu  

Publisher： John Wiley & Sons Inc‎

Publication year： 2009

E-ISBN: 9780470747797

P-ISBN(Hardback):  9780470741375

Subject： TQ Chemical Industry

Language： ENG

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Description

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials.

Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include:

  • biomarkers for nanotoxicity assessment
  • nanotoxicity assessment by gene expression analysis
  • in vivo and in vitro models for nanotoxicity testing
  • mechanisms of nanotoxicity
  • pharmakokinetics of nanomaterials
  • nanotoxicity of foods including food processing, food packaging and food safety
  • nanotoxicity of drugs including drug development and drug delivery
  • nanotoxicity of cosmetics and consumer products
  • health and environmental impact of nanotoxicity
  • safety evaluation of nanomaterials
  • regulatory impact of nanomaterials

Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Chapter

Contents

pp.：  9 – 13

Preface

pp.：  13 – 15

List of Contributors

pp.：  15 – 21

Acknowledgments

pp.：  21 – 23

1 Characterization of Nanomaterials for Toxicological Evaluation

pp.：  23 – 51

2 Criteria and Implementation of Physical and Chemical Characteristics of Nanomaterials for Human Health Effects and Ecological Toxicity Studies

pp.：  51 – 63

3 Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines

pp.：  63 – 83

4 High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm

pp.：  83 – 103

5 Application of Zinc Oxide Quantum Dots in Food Safety

pp.：  103 – 119

6 Evaluation of Nanotoxicity of Foods and Drugs: Biological Properties of Red Elemental Selenium at Nano Size (Nano-Se) In Vitro and In Vivo

pp.：  119 – 137

7 Evaluation of Toxicity of Nanostructures in Biological Systems

pp.：  137 – 183

8 Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials

pp.：  183 – 193

9 Nanoparticles: Is Neurotoxicity a Concern?

pp.：  193 – 205

10 Hepatotoxic Potential of Nanomaterials

pp.：  205 – 213

11 Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets

pp.：  213 – 249

12 Sources, Fate and Effects of Engineered Nanomaterials in the Aquatic Environment

pp.：  249 – 269

13 Nanotoxicity of Metal Oxide Nanoparticles in Vivo

pp.：  269 – 293

14 In Vivo Hypersensitive Pulmonary Disease Models for Nanotoxicity

pp.：  293 – 301

15 In Vivo and In Vitro Models for Nanotoxicology Testing

pp.：  301 – 325

16 In Vitro and In Vivo Toxicity Study of Nanoparticles

pp.：  325 – 357

17 In Vitro and In Vivo Models for Nanotoxicity Testing

pp.：  357 – 371

18 In Vitro Models for Nanotoxicity Testing

pp.：  371 – 401

19 In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles

pp.：  401 – 419

20 Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms

pp.：  419 – 449

21 Toxicity Testing and Evaluation of Nanoparticles: Challenges in Risk Assessment

pp.：  449 – 481

22 Evaluating Strategies For Risk Assessment of Nanomaterials

pp.：  481 – 521

23 Strategies for Risk Assessment of Nanomaterials

pp.：  521 – 541

24 Metal Nanoparticle Health Risk Assessment

pp.：  541 – 565

25 Application of Toxicology Studies in Assessing the Health Risks of Nanomaterials in Consumer Products

pp.：  565 – 603

26 Safety Assessment of Engineered Nanomaterials in Direct Food Additives and Food Contact Materials

pp.：  603 – 619

Index

pp.：  619 – 633

Color Plate

pp.：  633 – 636

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