Protein Chaperones and Protection from Neurodegenerative Diseases ( Wiley Series in Protein and Peptide Science )

Publication series ：Wiley Series in Protein and Peptide Science

Author： Stephan N. Witt  

Publisher： John Wiley & Sons Inc‎

Publication year： 2011

E-ISBN: 9781118063880

P-ISBN(Hardback):  9780470569078

Subject： R741.02 nerve pathology, etiology

Language： ENG

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Description

How protein chaperones protect cells from neurodegenerative diseases

Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases.

Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone properties. The intersection of molecular chaperones and neurodegeneration is an intensely studied area, partly because of the potential for manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases, and partly because of the ever-aging global population.

Discussing the potential to harness the power of protein chaperones, and future directions for research, discovery, and therapeutics, this book is essential reading for scientists working in the fields of biochemistry, molecular medicine, pharmacology and drug discovery, biotechnology and pharmaceutical companies, advanced students, and anyone interested in this cutting-edge topic.

Chapter

CONTENTS

pp.：  7 – 9

Preface

pp.：  9 – 11

Introduction

pp.：  11 – 15

Contributors

pp.：  15 – 17

1 Intrinsically Disordered Chaperones and Neurodegeneration

pp.：  17 – 81

2 Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases

pp.：  81 – 117

3 Chaperone-Mediated Autophagy and Parkinson’s Disease

pp.：  117 – 155

4 Chaperone and Anti-Chaperone Properties of Synuclein: Implications for Development, Aging, and Neurodegenerative Disease

pp.：  155 – 195

5 The Ubiquitin–Proteasome System in Neurodegenerative Diseases: More than the Usual Suspects

pp.：  195 – 227

6 Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery

pp.：  227 – 251

7 Amyloid Remodeling by Hsp104

pp.：  251 – 277

8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity

pp.：  277 – 293

9 Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners

pp.：  293 – 331

10 ALS and the Copper Chaperone CCS

pp.：  331 – 375

11 Emerging Area: TorsinA, a Novel ATP-Dependent Factor Linked to Dystonia

pp.：  375 – 401

12 Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones

pp.：  401 – 439

Index

pp.：  439 – 448

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