The Ubiquitous Roles of Cytochrome P450 Proteins ：Metal Ions in Life Sciences ( Metal Ions in Life Sciences )

Publication subTitle ：Metal Ions in Life Sciences

Publication series ：Metal Ions in Life Sciences

Author： Astrid Sigel  

Publisher： John Wiley & Sons Inc‎

Publication year： 2007

E-ISBN: 9780470028148

P-ISBN(Hardback):  9780470016725

Subject： Q559 synthetase

Language： ENG

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Description

Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons launch a new Series “Metal Ions in Life Sciences”.

There exists a whole range of books on Cytochromes P450, but none with the focus of this volume. This new volume in the Series concentrates on current hot topics in the area and tries to work out the underlying common developments.

As a result the reader will find a systematic account of new results in this exciting research area. The table of contents gives an idea on the wide span of chapters, starting with overviews and the presentation of specific systems, and ending with chapters on carbon-carbon bond cleavage by P450 sytems, drug metabolism as catalyzed by P450 systems, decomposition of xenobiotics by P450 enzymes and design and engineering of new P450 systems.

Chapter

Historical Development and Perspectives of the Series

pp.：  7 – 9

Preface to Volume 3

pp.：  9 – 11

Contents

pp.：  11 – 19

Contributors to Volume 3

pp.：  19 – 23

Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series

pp.：  23 – 25

Contents of Volumes in the Metal Ions in Life Sciences Series

pp.：  25 – 29

1 Diversities and Similarities in P450 Systems: An Introduction

pp.：  29 – 55

2 Structural and Functional Mimics of Cytochromes P450

pp.：  55 – 85

3 Structures of P450 Proteins and Their Molecular Phylogeny

pp.：  85 – 125

4 Aquatic P450 Species

pp.：  125 – 155

5 The Electrochemistry of Cytochrome P450

pp.：  155 – 185

6 P450 Electron Transfer Reactions

pp.：  185 – 215

7 Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties

pp.：  215 – 263

8 Cytochromes P450 – Structural Basis for Binding and Catalysis

pp.：  263 – 295

9 Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems

pp.：  295 – 313

10 Interactions of Cytochrome P450 with Nitric Oxide and Related Ligands

pp.：  313 – 347

11 Cytochrome P450-Catalyzed Hydroxylations and Epoxidations

pp.：  347 – 389

12 Cytochrome P450 and Steroid Hormone Biosynthesis

pp.：  389 – 425

13 Carbon-Carbon Bond Cleavage by P450 Systems

pp.：  425 – 465

14 Design and Engineering of Cytochrome P450 Systems

pp.：  465 – 505

15 Chemical Defense and Exploitation. Biotransformation of Xenobiotics by Cytochrome P450 Enzymes

pp.：  505 – 589

16 Drug Metabolism as Catalyzed by Human Cytochrome P450 Systems

pp.：  589 – 619

17 Cytochrome P450 Enzymes: Observations from the Clinic

pp.：  619 – 647

Subject Index

pp.：  647 – 680

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