Signal Transduction and Human Disease

Author： Toren Finkel  

Publisher： John Wiley & Sons Inc‎

Publication year： 2003

E-ISBN: 9780471448372

P-ISBN(Hardback):  9780471020110

Subject： R361 Pathological Anatomy and Histology

Language： ENG

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Description

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Chapter

CONTENTS

pp.：  9 – 11

Acknowledgments

pp.：  11 – 13

Contributors

pp.：  13 – 17

Introduction

pp.：  17 – 21

1 Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals

pp.：  21 – 43

2 NF-kB:A Key Signaling Pathway in Asthma

pp.：  43 – 91

3 Molecular Mechanisms of Cancer

pp.：  91 – 163

4 Apoptotic Pathways in Cancer Progression and Treatment

pp.：  163 – 191

5 Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes

pp.：  191 – 221

6 Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases

pp.：  221 – 253

7 Bacterial Regulation of the Cytoskeleton

pp.：  253 – 279

8 Bacterial Toxins and Diarrhea

pp.：  279 – 299

9 Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways

pp.：  299 – 327

10 Mast Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies

pp.：  327 – 377

11 Rheumatology and Signal Transduction

pp.：  377 – 397

12 Molecular Mechanisms of Neurodegenerative Disorders

pp.：  397 – 431

13 Neurotrophic Signaling in Mood Disorders

pp.：  431 – 467

14 Inhibiting Signaling Pathways Through Rational Drug Design

pp.：  467 – 479

Index

pp.：  479 – 490

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