Author： Chisholm Maureen Dwan'isa Jean-Pierre Latere Thakur Sona Maryanoff Cynthia
Publisher： Taylor & Francis Ltd
ISSN： 1023-666X
Source： International Journal of Polymer Analysis and Characterization, Vol.14, Iss.2, 2009-02, pp. : 126-139
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Abstract
This work describes a method for analyzing polymer concentration in solution using density. The method can be applied to any polymer/solvent combination given certain experimental conditions; however, this study is specific to commercial samples of poly (n-butyl methacrylate) (PBMA) or poly (ethylene-co-vinyl acetate) (PEVA), two polymers of interest to Cordis Corporation. The test method was validated with respect to ICH requirements of linearity, accuracy, precision, range, etc.[1,2] The kinetic dissolution of PBMA or PEVA in tetrahydrofuran (THF) was evaluated as a practical analysis of Cordis process parameters. The results are provided as examples of the test method application.
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