Bioactive phenolics from Seriphidium stenocephalum

ISSN： 1028-6020

Source： Journal of Asian Natural Products Research, Vol.15, Iss.3, 2013-03, pp. : 286-293

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Abstract

Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5′-trihydroxy-3′,4′,6-trimethoxyflavone (5), 5,6,7,5′-tetrahydroxy-4′-methoxyflavone (6), and axillaroside (7). All isolates were characterized with the help of spectroscopic data including 1D, 2D NMR, and high resolution mass spectrometry and/or in comparison with the related compounds in literature. All compounds were tested for in vitro enzyme inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and lipoxygenase. Compounds 1 and 4–7 exhibited significant activity against all the tested enzymes, whereas compounds 2 and 3 were found inactive.

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