Commercial Chiral Stationary Phases for the Separations of Clinical Racemic Drugs

ISSN： 1542-2119

Source： Separation and Purification Reviews, Vol.36, Iss.4, 2007-10, pp. : 285-481

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Abstract

The enantioseparation of clinically used racemic drugs by liquid chromatography on commercial chiral stationary phases (CSPs) available in 2006 is reviewed. The CSPs are briefly described. The data was extracted and compiled from the ChirBase database (Marseille, France). All the drugs included are listed according to the Anatomical Therapeutic Chemical (ATC) classification that defined thirteen therapeutic classes. Only positive results are reported and, for a given CSP type, only the set of analytical conditions providing the best enantioselectivity is provided. The analyst can find at a glance the optimal CSP column and its supplier, as well the suitable mobile phase allowing for an efficient enantioresolution of a given racemic drug. Given the amount of data, Part I of this compilation includes the commercial CSP description and only the 6 opening ATC classes from Class 1: "Alimentary tract and metabolism" to Class 6: "Cardiovascular system." Part II includes the 7 remaining classes. Part III will include chiral separations done using supercritical fluid chromatography.