Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

Author: Brown Kyle M.   Costanzo Marna S.   Xu Wenxin   Roy Scott   Lozovsky Elena R.   Hartl Daniel L.  

Publisher: Oxford University Press

ISSN: 0737-4038

Source: Molecular Biology and Evolution, Vol.27, Iss.12, 2010-12, pp. : 2682-2690

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Abstract