Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice

By Lloret Alejandro   Dragileva Ella   Teed Allison   Espinola Janice   Fossale Elisa   Gillis Tammy   Lopez Edith   Myers Richard H.   MacDonald Marcy E.   Wheeler Vanessa C.  

Human Molecular Genetics, Vol. 15, Iss. 12, 2006-06 ,pp. : 2015-2024

Oxford University Press

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Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease

By Van Raamsdonk Jeremy M.   Murphy Zoe   Slow Elizabeth J.   Leavitt Blair R.   Hayden Michael R.  

Human Molecular Genetics, Vol. 14, Iss. 24, 2005-12 ,pp. : 3823-3835

Oxford University Press

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

By Kuhn Alexandre   Goldstein Darlene R.   Hodges Angela   Strand Andrew D.   Sengstag Thierry   Kooperberg Charles   Becanovic Kristina   Pouladi Mahmoud A.   Sathasivam Kirupa   Cha Jang-Ho J.   Hannan Anthony J.   Hayden Michael R.   Leavitt Blair R.   Dunnett Stephen B.   Ferrante Robert J.   Albin Roger   Shelbourne Peggy   Delorenzi Mauro   Augood Sarah J.   Faull Richard L.M.   Olson James M.   Bates Gillian P.   Jones Lesley   Luthi-Carter Ruth  

Human Molecular Genetics, Vol. 16, Iss. 15, 2007-08 ,pp. : 1845-1861

Oxford University Press

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Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative

By Tebbenkamp Andrew T.N.   Green Cameron   Xu Guilian   Denovan-Wright Eileen M.   Rising Aaron C.   Fromholt Susan E.   Brown Hilda H.   Swing Debbie   Mandel Ronald J.   Tessarollo Lino   Borchelt David R.  

Human Molecular Genetics, Vol. 20, Iss. 14, 2011-07 ,pp. : 2770-2782

Oxford University Press

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Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice

By Mughal Mohamed R.   Baharani Akanksha   Chigurupati Srinivasulu   Son Tae Gen   Chen Edmund   Yang Peter   Okun Eitan   Arumugam Thiruma   Chan Sic L.   Mattson Mark P.  

Human Molecular Genetics, Vol. 20, Iss. 10, 2011-05 ,pp. : 2078-2078

Oxford University Press

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