

Author: Sutton Beth S. Crosslin David R. Shah Svati H. Nelson Sarah C. Bassil Anthony Hale A. Brent Haynes Carol Goldschmidt-Clermont Pascal J. Vance Jeffery M. Seo David Kraus William E. Gregory Simon G. Hauser Elizabeth R.
Publisher: Oxford University Press
ISSN: 1460-2083
Source: Human Molecular Genetics, Vol.17, Iss.9, 2008-05, pp. : 1318-1328
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Abstract
Platelet-activating factor acetylhydrolase (PLA2G7) is a potent pro- and anti-inflammatory molecule that has been implicated in multiple inflammatory disease processes, including cardiovascular disease. The goal of this study was to investigate the genetic effects of PLA2G7 on coronary artery disease (CAD) risk in two large, independent datasets with CAD. Using a haplotype tagging (ht) approach, 19 ht single nucleotide polymorphisms (SNPs) were genotyped in CATHGEN casecontrol samples (cases 806 and controls 267) and in the GENECARD Family Study (
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