Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice

By Kwon Deborah Y.   Motley William W.   Fischbeck Kenneth H.   Burnett Barrington G.  

Human Molecular Genetics, Vol. 20, Iss. 18, 2011-09 ,pp. : 3667-3677

Oxford University Press

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Histone deacetylase inhibition suppresses myogenin-dependent atrogene activation in spinal muscular atrophy mice

By Bricceno Katherine V.   Sampognaro Paul J.   Van Meerbeke James P.   Sumner Charlotte J.   Fischbeck Kenneth H.   Burnett Barrington G.  

Human Molecular Genetics, Vol. 21, Iss. 20, 2012-10 ,pp. : 4448-4459

Oxford University Press

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Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect

By Gavrilina Tatiana O.   McGovern Vicki L.   Workman Eileen   Crawford Thomas O.   Gogliotti Rocky G.   DiDonato Christine J.   Monani Umrao R.   Morris Glenn E.   Burghes Arthur H.M.  

Human Molecular Genetics, Vol. 17, Iss. 8, 2008-04 ,pp. : 1063-1075

Oxford University Press

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Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice

By Heier Christopher R.   Satta Rosalba   Lutz Cathleen   DiDonato Christine J.  

Human Molecular Genetics, Vol. 19, Iss. 20, 2010-10 ,pp. : 3906-3918

Oxford University Press

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Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

By Hauke Jan   Riessland Markus   Lunke Sebastian   Eypoglu Ilker Y.   Blmcke Ingmar   El-Osta Assam   Wirth Brunhilde   Hahnen Eric  

Human Molecular Genetics, Vol. 18, Iss. 2, 2009-01 ,pp. : 304-317

Oxford University Press

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