Duplication of Glu 37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

Author： Gremer Lothar   De Luca Alessandro   Merbitz-Zahradnik Torsten   Dallapiccola Bruno   Morlot Susanne   Tartaglia Marco   Kutsche Kerstin   Ahmadian Mohammad Reza   Rosenberger Georg  

Publisher： Oxford University Press

ISSN： 1460-2083

Source： Human Molecular Genetics, Vol.19, Iss.5, 2010-03, pp. : 790-802

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