Author： Montag M van der Ven K Ved S Schmutzler A Prietl G Krebs D Peschka B Schwanitz G Albers P Haidl G van der Ven H
Publisher： Oxford University Press
ISSN： 1460-2350
Source： Human Reproduction, Vol.12, Iss.12, 1997-12, pp. : 2635-2640
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Abstract
This paper reports on results of intracytoplasmic sperm injection (ICSI) in patients in whom constitutional or secondary chromosome aberrations were detected in the male and/or female partner. Out of 434 couples treated by ICSI (590 cycles), 16 couples (3.7%) were affected by constitutional chromosome aberrations and 96 (22.1%) by secondary chromosome aberrations. Constitutional chromosome aberrations were found in eight male and eight female patients. Couples with the aberration in the male showed significantly lower fertilization, implantation and pregnancy rates (P < 0.05).="" the="" occurrence="" of="" female="" constitutional="" chromosome="" aberrations="" led="" to="" lower="" fertilization="" rates="" but="" implantation="" and="" pregnancy="" rates="" were="" similar="" to="" a="" control="" group;="" however,="" a="" higher="" abortion="" rate="" was="" noted.="" in="" the="" group="" with="" secondary="" chromosome="" aberrations,="" 22="" males="" and="" 59="" females="" carried="" an="" abnormality="" and="" in="" 15="" couples,="" both="" partners.="" compared="" to="" the="" remaining="" (unaffected)="" 322="" couples,="" fertilization="" and="" embryo="" transfer="" rates="" were="" reduced="" but="" implantation="" rates="" and="" pregnancy="" rates="" were="" not="" different.="" in="" all="" couples="" where="" an="" abortion="" occurred,="" mainly="" parental="" autosomal="" aberrations="" were="" involved="" (six="" out="" of="" eight).="" our="" retrospective="" analysis="" shows="" that="" an="" unexpectedly="" high="" number="" of="" infertile="" couples="" in="" an="" icsi="" programme="" are="" affected="" by="" chromosome="" aberrations,="" which="" in="" turn="" may="" explain="" the="" reduced="" fertilization="" rates="" observed="" in="" this="" subgroup="" of="" patients.="">
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