Fertilization and early embryology. Shortened exposure of oocytes to spermatozoa improves in-vitro fertilization outcome: a prospective, randomized, controlled study

Author： Dirnfeld M.

Publisher： Oxford University Press

ISSN： 1460-2350

Source： Human Reproduction, Vol.14, Iss.10, 1999-10, pp. : 2562-2564

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

A prospective, randomized study of 158 patients undergoing in-vitro fertilization (IVF) and embryo transfer was conducted to evaluate whether a shortened exposure of oocytes to spermatozoa enhances oocyte development, and subsequently influences the IVF outcome. A comparison was made between conventional treatment time and shorter exposure of retrieved oocytes to spermatozoa. Fertilization and cleavage rates, embryo quality, implantation and pregnancy rates in the study group (short exposure) versus controls (standard IVF procedure) were evaluated. Fertilization (56 versus 61%) and cleavage rates (96 versus 92%) were similar in the two groups respectively. However, embryo quality was significantly higher in the study group (P < 0.05).="" moreover,="" the="" pregnancy="" and="" implantation="" rates="" were="" significantly="" increased="" (42.4="" versus="" 26%="" per="" embryo="" transfer,="" and="" 16="" versus="" 10%="" respectively;="">P < 0.05).="" our="" results="" demonstrated="" that="" shorter="" exposure="" of="" oocytes="" to="" spermatozoa="" is="" superior="" to="" the="" standard="" time="" in="" ivf="" and="" may="" have="" a="" favourable="" effect="" on="" implantation="" rates="" by="" improving="" embryo="" quality.="">