Author： Coroleu Buenaventura Barri Pedro N. Carreras Olga Martínez Francisca Parriego Mónica Hereter Lourdes Parera Nuria Veiga Anna
Publisher： Oxford University Press
ISSN： 1460-2350
Source： Human Reproduction, Vol.17, Iss.2, 2002-02, pp. : 341-346
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Abstract
BACKGROUND: Traditionally, embryo transfer after IVF has been performed blindly and placing the embryos ~1 cm below the fundal endometrial surface. However, it has been suggested that transferring embryos rather lower in the uterine cavity or high in the uterus may improve implantation rates. Nevertheless, there has not yet been a controlled trial to prove this theory. This prospective randomized study investigates the influence of the depth of embryo replacement on the implantation rate after embryo transfer carried out under transabdominal ultrasound guidance. METHODS: A total of 180 consecutive patients undergoing ultrasound-guided embryo transfer were randomized to three study groups according to the distance between the tip of the catheter and the uterine fundus at the moment of the embryo deposition in the lumen of the endometrial cavity: group 1: 10 ± 1.5 mm; group 2: 15 ± 1.5 mm; group 3: 20 ± 1.5 mm. RESULTS: There was equal distribution between all three study groups regarding the main demographic and baseline characteristics of the patients, ovarian response, oocyte retrieval and IVF outcome, as well as the characteristics of embryo transfer and luteal phase support. The position of the catheter tip in relation to the fundal endometrial surface in groups 1 (10.2 ± 0.9 mm), 2 (14.6 ± 0.7 mm) and 3 (19.3 ± 0.8 mm) was significantly different. Implantation rate was significantly higher (P < 0.05)="" in="" groups="" 2="" (31.3%)="" and="" 3="" (33.3%)="" compared="" with="" group="" 1="" (20.6%).="" conclusions:="" the="" depth="" of="" the="" embryo="" replacement="" into="" the="" uterine="" cavity="" may="" influence="" implantation="" rates,="" and="" thus="" it="" should="" be="" considered="" as="" an="" additional="" procedure="" among="" factors="" recently="" proposed="" as="" associated="" with="" successful="" embryo="" transfer="" after="" ivf.="">
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