A prospective randomized study: day 2 versus day 5 embryo transfer

Author： Van der Auwera Ingrid Debrock Sophie Spiessens Carl Afschrift Hilde Bakelants Els Meuleman Christel Meeuwis Luc D'Hooghe Thomas M.

Publisher： Oxford University Press

ISSN： 1460-2350

Source： Human Reproduction, Vol.17, Iss.6, 2002-06, pp. : 1507-1512

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Abstract

BACKGROUND: This randomized controlled study was performed in an unselected IVF/ICSI population to test the hypothesis that blastocyst transfers result in higher clinical pregnancy rates (CPR) per oocyte retrieval when compared with day 2 transfers. METHODS: Blind randomization for transfer on day 2 (group 1) or day 5/6 (group 2) was performed before stimulation. Oocytes and embryos were cultured in sequential media in 5.5% CO2, 5% O2, 89.5% N2 and 90% humidity. A maximum of two embryos was transferred. RESULTS: The two groups were similar for age, IVF indication, number of treatment cycles, rate of ICSI/IVF, number of fertilized oocytes and number of embryos transferred. The CPR/oocyte retrieval was comparable in group 1 (32%) and in group 2 (44%), while the CPR/embryo transfer was significantly higher (P < 0.01)="" in="" group="" 2="" (60%)="" than="" in="" group="" 1="" (35%).="" similarly,="" the="" implantation="" rate="" per="" embryo="" transferred="" was="" significantly="" higher="">P < 0.03)="" in="" group="" 2="" (46%)="" than="" in="" group="" 1="" (29%).="" the="" cryo-augmented="" delivery="" rate/oocyte="" retrieval="" was="" comparable="" in="" group="" 2="" (36.3%)="" and="" in="" group="" 1="" (28.6%).="" conclusion:="" this="" randomized="" study="" in="" an="" unselected="" population="" showed="" a="" significantly="" higher="" cpr/embryo="" transfer="" and="" a="" tendency="" toward="" a="" higher="" cpr/oocyte="" retrieval="" in="" patients="" receiving="" blastocysts="" when="" compared="" with="" day="" 2="" transfers.="">