Acquired haemophilia due to factor VIII inhibitors in ovarian hyperstimulation syndrome: Case report

Author: Nakauchi‐Tanaka Tomoko  

Publisher: Oxford University Press

ISSN: 1460-2350

Source: Human Reproduction, Vol.18, Iss.3, 2003-03, pp. : 506-508

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Abstract

A 31‐year‐old nulligravida woman developed an acquired factor VIII inhibitor associated with severe ovarian hyperstimulation syndrome (OHSS). She developed haematouria, ecchymosis, and intramuscular bleeding following the severe OHSS. Laboratory examinations showed a markedly prolonged activated partial thromboplastin time and a low level of factor VIII activity. Treatment with prothrombin complex concentrate and factor VIII inhibitor bypassing agent was successful in reducing the inhibitor so that she delivered a healthy baby via spontaneous vaginal delivery. Acquired haemophilia is a life‐threatening disorder. This is the first case report of acquired haemophilia in OHSS.

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