In vitro hepatic biotransformation of aldrin and dieldrin in food-producing animals

Author: Furusawa N.   Morita Y.  

Publisher: Akademiai Kiado

ISSN: 0236-6290

Source: Acta Veterinaria Hungarica, Vol.49, Iss.3, 2001-08, pp. : 349-353

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Abstract

The hepatic biotransformation of aldrin (AD) and dieldrin (DD) was studied in liver post-mitochondrial supernatants (S-9s) from laying hens, female cattle and swine. S-9s were incubated with 0.03 nmol of AD or DD for 1 h. After 1 h, AD in the samples was almost epoxidated to DD. This formation was found with all the animal S-9s, and the highest rates occurred in pig S-9 (P < 0.01), followed by cow and hen S-9s. No reduction of DD was found with any of the S-9s.