Author： Aune Thomas
Publisher： Humana Press, Inc
ISSN： 0257-277X
Source： Immunologic Research, Vol.23, Iss.2-3, 2001-06, pp. : 193-204
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Abstract
Our laboratory employs reporter transgenic mice as model systems to study the transcriptional reprogramming that accompanies Thelper cell differentiation. These studies demonstrate that changes in the activity of simple transcriptional elements associated with the IFN-γ gene can recapitulate alterations in gene expression. In addition, our studies have revealed a key role for the transcription factor, CAMP response element binding protein (CREB), in the protection of differentiating T cells from apoptosis. Together, these findings further our understanding of the logic employed by T cells to alter gene expression profiles in response to differentiation signals.
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