Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia

Author: Wu Yan   Ye Xi-Hong   Guo Pei-Pei   Xu San-Peng   Wang Jie   Yuan Shi-Ying   Yao Shang-Long   Shang You  

Publisher: Humana Press, Inc

ISSN: 0895-8696

Source: Journal of Molecular Neuroscience, Vol.42, Iss.2, 2010-10, pp. : 226-234

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Abstract

Neuroprotective effect of lipoxin A4 methyl ester (LXA4 ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA4 ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA4 ME ameliorated neurological deficit, reduced infarct volume, attenuated histological damage, and decreased number of apoptotic neuron induced by ischemic insult. These neuroprotective effects of LXA4 ME were associated with inhibition of neutrophil infiltration, lipid peroxidation, and astrocyte activation. In addition, LXA4 ME also attenuated proinflammatory cytokines (TNF-α and IL-1β) production. These data suggest that LXA4 ME protects neuron against permanent cerebral ischemia by inhibiting inflammatory responses.

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