Human Monoclonal Antibodies: Immune Complexes and Cryoglobulins

Author: Bernier George M.  

Publisher: OceanSide Publications, Inc

ISSN: 1539-6304

Source: Allergy and Asthma Proceedings, Vol.3, Iss.2, 1982-0, pp. : 304-307

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Of the several types of cryoglobulinemia, those associated with large amounts of monoclonal protein with antibody activity directed against a serum component may behave as an immune complex. The extremely large amount of monoclonal protein and its immune complex nature may allow prolonged activation of inflammatory mediators such as complement. Two discrete syndromes, that of Mixed Cryoglobulinemia and that of anti-albumin monoclonal antibodies are reviewed in this article.