Solvent‐Free Rapid Deprotection of Ketone and Aldehyde Oximes using Periodic Acid

Author: Li Zheng   Ding Run   Xing Yu   Shi Sheng  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.35, Iss.19, 2005-10, pp. : 2515-2520

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Abstract

Ketone and aldehyde oximes can be readily converted to the corresponding carbonyl compounds in high yields under solvent-free conditions when treated with periodic acid. Oximes bearing aliphatic C=C bonds can be selectively deoximated. The advantages of this protocol include a rapid reaction rate and a simple workup procedure. No volatile organic solvents are required in the reaction processes.