Novel Approach to 3‐Methyl‐1H‐quinoxalin‐2‐ones

Author: Li Xun   Wang Donghua   Wu Jifeng   Xu Wenfang  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.35, Iss.19, 2005-10, pp. : 2553-2560

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Abstract

A novel approach to the synthesis of 3-methyl-1H-quinoxalin-2-ones has been described. These compounds were regioselectively prepared by starting from substituted phenylamines and a-chloropropionyl chloride through the efficient procedures of acylation, nitration, reduction, intramolecular alkylation, and oxidation.

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