Simple Reduction of Heteroaromatic Esters to Alcohols Using a Sodium Borohydride–Methanol System

Author: Boechat Núbia   da Costa Jorge   Mendonça Jorge   Paes Karla   Fernandes Elisa   de Oliveira Pedro   Vasconcelos Thatyana   de Souza Marcus  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.35, Iss.24, 2005-12, pp. : 3187-3190

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Abstract

Some heteroaromatic esters were reduced to the corresponding alcohols by using a sodium borohydride–methanol system. The reduction was completed within 0.15–2.0 h in refluxing THF. The alcohol products were isolated after aqueous workup in moderate to excellent yield (48–97%).

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