Author： Sridhar Gowri Raghunathan R.
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.36, Iss.1, 2006-02, pp. : 21-29
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Abstract
The 1,3-dipolar cycloaddition of an azomethine ylide, generated from isatin and sarcosine by a decarboxylative route with various p -substituted 3,5 bis(aryl methylidene)N-methyl-4-piperidinones in refluxing methanol, proceeded regioselectively to give novel dispiroheterocycles. The product on subsequent annulation with hydrazine hydrate afforded 1-N-methyl-spiro[2.3']oxindole-spiro[3.7?](3?-aryl)-5?-methyl-3?,3a?,4?,5?,6?,7?-hexahydro-2H-pyrazolo[4,3- c ]pyridine-4-aryl-pyrrolidines in good yield.
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