Convenient One-Pot Preparation of Dimethyl Bicyclo[2.2.2]octane-1,4-dicarbolylate, a Key Intermediate for a Novel Adenosine A1 Receptor Antagonist

Author： Chang HeXi   Kiesman William F.   Petter Russell C.  

Publisher： Taylor & Francis Ltd

ISSN： 0039-7911

Source： Synthetic Communications, Vol.37, Iss.8, 2007-01, pp. : 1267-1272

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Abstract

Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate (4), a key starting material for a novel adenosine A1 receptor antagonist, was prepared in a one-pot reaction with convenient workup and improved yield.

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