N-Chlorosuccinimide/1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)-Mediated Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles

Author: Pardeshi Santosh   Patil Sachin   Bobade Vivek  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.40, Iss.11, 2010-01, pp. : 1601-1606

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Abstract

A mixture of N-chlorosuccinimide and 1,8-diazabicyclo[5.4.0]undec-7-ene oxidatively cyclizes structurally diverse acyl hydrazone, thereby providing an efficient and convenient method for the synthesis of various 2,5-disubstituted 1,3,4-oxadiazoles. The salient features of this method are mild reaction conditions, short reaction time, excellent yields, and simple workup procedure.

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