Author： Saboktakin Mohammad Reza Maharramov Abel Ramazanov Mohammad Ali
Publisher： Taylor & Francis Ltd
ISSN： 0360-2559
Source： Polymer-Plastics Technology and Engineering, Vol.49, Iss.1, 2010-01, pp. : 104-109
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Abstract
Magnetic nanoparticles have been proposed for use as biomedical purposes to a large extent for several years. In this paper we discuss the preparation and characterization of superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) coated with acetyled - PAMAM dendrimers(Ac-PAMAM). Also, in the present study, the conjugate (Ac-PAMAM)/SPIO nanoparticles were exhaustivly studied as controlled-release systems for parenteral administration of a model drug 5-aminosalicyclic acid (mesalamine) and analyzed using various release kinetic studies. The nanoparticles thus synthesized have been characterized by a Fourier Transform Infrared (FTIR) spectrophotometer and with X-ray diffraction. The morphology of these nanoparticles was studied by scanning electron microscopy (SEM).
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