

Author: Albersen Arjan Porcelijn Leendert Schilders Joyce Zuetenhorst Hanneke Njo Tjin Hamberg Paul
Publisher: Informa Healthcare
ISSN: 1369-1635
Source: Platelets, Vol.24, Iss.7, 2013-11, pp. : 566-570
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Abstract
Thrombocytopenia is a well-documented adverse reaction of sunitinib. Thrombocytopenia was observed in a patient with metastatic renal clear-cell carcinoma undergoing sunitinib treatment. Platelet count in an ethylenediaminetetraacetic acid (EDTA) sample was 19 × 109/l. To exclude pseudothrombocytopenia (PTCP), a platelet count in citrate-anticoagulated blood was performed, showing a platelet count of 6 × 109/l. Due to the apparent thrombocytopenia, the patient received platelet concentrates. Subsequent analyses revealed PTCP whereby platelet clumping was most abundant in citrate – followed by EDTA- and heparin-anticoagulated blood samples. This effect was partially reversed after placing blood samples at 37°C. The IgM antiplatelet autoantibodies responsible for
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