Increased Expression of Cardiac Phosphatases in Patients with End-stage Heart Failure

Author: Neumann J.   Eschenhagen T.   Jones L.R.   Linck B.   Schmitz W.   Scholz H.   Zimmermann N.  

Publisher: Academic Press

ISSN: 0022-2828

Source: Journal of Molecular and Cellular Cardiology, Vol.29, Iss.1, 1997-01, pp. : 265-272

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Abstract

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.