Author: Neumann J. Eschenhagen T. Jones L.R. Linck B. Schmitz W. Scholz H. Zimmermann N.
Publisher: Academic Press
ISSN: 0022-2828
Source: Journal of Molecular and Cellular Cardiology, Vol.29, Iss.1, 1997-01, pp. : 265-272
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Abstract
Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.
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