Author: Hurtado C. Pierce G.N.
Publisher: Academic Press
ISSN: 0022-2828
Source: Journal of Molecular and Cellular Cardiology, Vol.32, Iss.10, 2000-10, pp. : 1897-1907
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Abstract
Stimulation of Na+/H+exchange during ischemia-reperfusion results in cardiac damage. However, it is unclear whether the Na+/H+exchanger is active during the ischemic period or during reperfusion. Adult beating cardiomyocytes were exposed to an ischemia mimetic solution for 90 min and then reperfused with a normal solution for 30 min. 5-(N,N-dimethyl)-amiloride (DMA), a blocker of the Na+/H+exchanger, was administered during ischemia and the first 3 min of reperfusion or only during the first 3 min of reperfusion. Administration of DMA only upon reperfusion resulted in increased cell survival (81±1%,
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